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In this section you will find interesting articles about complementary and alternative medicine, written by the foundation IOCOB

Ozon therapy for Lyme: facts or church?

We analysed a debate on Facebook between a physician interested in complementary medicine (Dr) and a group called Ozon-wellness, supporting the use of ozone therapy in Lyme. The answers are from the Lyme group coordinator/moderator (L). Although the group was called Ozon Wellness, it basically was a group of patients interested in Lyme related to […]

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Informazioni per gli specialisti, i medici di base e i farmacisti: palmitoiletanolamide (PEA), un antidolorifico convalidato da EBM (evidence-based medicine), in vendita come PeaVera

Palmitoiletanolamide come antidolorifico PeaVera®: prodotto nei Paesi Bassi La palmitoiletanolamide (PEA) è disponibile in tutto il mondo dal 2012, come antidolorifico PeaVera. PeaVera viene prodotto nei Paesi Bassi, in uno stabilimento certificato GMP. La PEA viene testata per la purezza in un laboratorio americano indipendente. Il certificato di analisi può essere consultato sul sito Web del fornitore di […]

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Theanine: a useful and a supplement, generally recognized as safe (GRAS)

What kinds of
theanine do we get on the market?

There are two
sorts of supplements available on the market:

1. a synthetic form, mostly branded under the name Suntheanine and
consisting of  purified L-theanine which
is derived from chemical, enzymatic synthesis and

2. a pure natural form,
l-theanine, consisting of the natural aminoacid in tea leaves and produced by a
natural fermentation process of these tea leaves.

The subject
ingredient of tea leaves, the compound L-theanine, is an amino acid which is
also known under different names, 
y-glutamylethylamide or N-ethyl-L-glutamine.

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Amyotrofe laterale sclerose: palmitoylethanolamide

We kennen de poster allemaal. "Ik ben inmiddels overleden", zoiets schokkends staat erop. Het gaat dan om sprekende koppen van mensen die ALS hadden en reeds overleden zijn.

Amyotrofe laterale sclerose (voor het eerst beschreven door de grote neuroloog Charcot in 1869) is een vreselijk ziektebeeld, dat snel progressief is, met spierverval en spierkracht afname, waarbij alle spieren aangedaan kunnen zijn. Tot en met de ademhalingsspieren toe. Een goede behandeling is er in wezen nog steeds niet. Mensen sterven meestal binnen enkele jaren.

Daarom zijn de resultaten uit een Italiaans revalidatie-kliniek op Sardinie  zo indrukwekkend. Twee ALS patienten werden daar behandeld met de natuurlijke ontstekingsremmende en pijnstillende lichaamseigen stof palmitoylethanolamide (PEA), dat verkrijgbaar is als het supplement a product which contains PEA. Positieve effecten waren vrijwel direct meetbaar.

Elders in de wereld zijn ALS patienten begonnen met het gebruik van PEA. Vooral patienten met de bulbaire vorm lijken relatief snel een positief effect te merken. Palmitoylethanolamide wordt door het lichaam zelf aangemaakt als reparatie molecuul bij ALS.

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PEA: informazioni palmitoilethanolamide

I neutraceutici PEA (PeaVera, Palmidrol, e altri PEA prodotti), sia palmitoiletanolamide antidolorifico naturale (PEA) contengono, aprendo la strada a un nuovo metodo naturale di trattamento del dolore cronico. Entrambi i prodotti sono realizzati secondo i più alti standard (GMP). Perché PEA nei Paesi Bassi solo dal 2010, e abbiamo anche molte domande per telefono, ecco un elenco di domande e risposte. Anche domande e commenti da parte di persone su Fori di discussione su PEA parlare, abbiamo elaborato.

Fine anno del 2012 nei Paesi Bassi, sono decine di migliaia di pazienti trattati con PEA. Non ci sono effetti collaterali significativi segnalati. PEA può essere senza problemi, oltre a prendere altri farmaci e medicinali.

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Pelvic Neuropathy by Pelvic Messenger

De invalshoek die we de laatste jaren ontwikkeld hebben, ‘iedereen heeft recht op pijnstilling zonder bijwerkingen’ krijgt ook in het buitenland steeds meer resonantie. De voorzitter van Stichting IOCOB was gast op een anderhalfuur durend interview over de behandeling van bekkenpijnen. De ‘show’ heet The Pelvic Messenger en werd door vele duizenden patienten beluisterd. Het interview is te horen op de link hieronder.

The Pelvic Messenger 

The show "The Pelvic Messenger" has been created as a live talk podcast which stems from the website PelvicMessenger. I, Jessica Mariotti Tomsic, have suffered from severe Chronic Neuropathic Pelvic Pain and multiple other co-morbidities.

My colleague, Elisabeth Oas, created this arena in which others can come and find resources, information and hope. It is our mission to help educate the patient on how to best get a complete diagnosis, more effective treatment, and eventually have a better quality of life. Please refer to for more info. You may also visit my blog at: for my personal story.

The guest is Prof. dr. Jan M. Keppel Hesselink, MD, MS, PhD, of the Institute for Neuropathic Pain in The Netherlands.

He will be discussing his strong interest in chronic pelvic pain and treatment modalities. I can assure my listeners they will always find something positive to inspire hope from this show. Knowing they are not alone and their is always a way in which to see better results, by addressing their own personal formula of success!!

Listen on:  

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Avoid magnesium stearate in supplements if possible

Magnesium stearate is widely used as an excipient in supplements, dietfood for medical purposes and drugs, because machines compressing tablets run more smooth if magnesium starate is added to tablets. Basically this thus has nothing to do with our body but all with the industriel proces of making tablets. We will give an example of two supplements, and bring arguments why one should chose the supplement devoid of magnesium stearate.

a product which contains PEA_and_peapure.gif

Magnesium stearate is the base of the a product which contains PEA tablets, and many people have asked in the past why does a product which contains PEA which contains the natural and body-own protective fatty compound palmitoylethanolamide, also contains such an unatural fat as magnesium stearate?

In the table both supplements are compared. a product which contains PEA contains magnesium stearate and a number of other excipients which have no use of the organism, but are only put in based for pharmaceutical and technical reasons for instance, to be able to press tablets more quickly. Therefore the purity of palmitoylethanolamide in each tablet or capsule is 30% lower in a product which contains PEA compared to PeaPure, which does not contain any excipients. But now the science why magnesium stearate is not such a good idea in foodsupplements.

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Glia modulation as a new key for analgesics

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Ueber PeaPure: wirksame Substanz, Palmitoylethanolamid

a product which contains PEA ist seit November 2012 in den Niederlanden nicht mehr verfügbar. a product which contains PEA in den Niederlanden wird durch PeaPure ersetzt.

Die Wirkung von Palmitoylethanolamid entfaltet sich durch natürliche Mechanismen des Körpers. Nach der Einnahme kommt es zu zahlreichen biologischen Prozessen in den Zellen. Dadurch kann es einige Wochen dauern, bevor die Wirkung spürbar ist.  

PeaPure ist nach neuesten wissenschaftlichen Erkenntnissen entwickelt.

PeaPure enthält Palmitoylethanolamid, wie a product which contains PEA. PeaPure wurde aber keinerlei chemischer Hilfsstoff, Geschmacksstoff, Farbstoff oder Süßstoff zugefügt. 
Dem Inhalt a product which contains PEA sachets enthalt Sorbitol. 
Es gibt Nutzer, die diesen Süßstoff nicht einnehmen möchten. 
PeaPure-Kapseln enthalten kein Sorbitol, einzig und allein Palmitoylethanolamid.

PeaPure nimmt man am besten während oder nach der Mahlzeit ein.
Es hat sich erwiesen, dass 3 Mal täglich 1 Kapsel à 400 mg eine gute Anfangsdosierung während der ersten 2 Monate ist.

Anwender van PeaPure spüren im Allgemeinen eine Verbesserung in den ersten Wochen der Einnahme. 
Erst nach zwei Monaten lässt sich die Wirkung von PeaPure wirklich beurteilen.

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Lou Gehrig’s disease (ALS) treated with palmitoylethanolamide

Palmitoylethanolamide  (PEA) is an anti-inflammatory body own molecule and might be able to fight off part of the neuro-inflammation in ALS. 

Simonetta Clemente (MD) from the Macomer Rehabilitation Center, Nuoro Health Care Center, Italy published an important mile stone paper in 2012, title: ‘Amyotrophic Lateral Sclerosis Treatment with Ultramicronized
Palmitoylethanolamide: A Case Report’.

In this paper she descibes the positive effect of the natural and body-own compound palmitoylethanolamide (PEA) in ALS, amyotrophic lateral sclerosis, a devasting neurological disorder also known as Lou Gehrig’s disease in the USA.

In her article she points out that PEA has potent anti-inflammatory activity in many acute and
inflammatory and chronic pain models, that PEA reduces spinal cord trauma
in mice, and has neuroprotective properties.

She refers to the recent findings from professor’s Cruccu’s group, that PEA has seen to
improve myelinated-fibre function in patients with
chemotherapy-induced painful neuropathy and to other recent publications were PEA was seen to reduce pain severity in patients with pain associated to
different pathological conditions who were undergoing
standard therapies with unsatisfactory results or in those
patients who discontinued standard therapy because of
important side effects.

Given the lack of an effective
therapy for ALS, as she correctly stated, she explored and reported the effects of PEA in a
case of ALS.   

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