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DMT: het molecuul der sjamanen

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DMT ontsluit visioenen en kan gezien worden als een sjamanistisch molecuul.
Ayahuasca thee bestanddelen bevatten DMT

Ayahuasca thee: de groene bladeren bevatten DMT, de bruine stengels bevatten een DMT-afbraak remmer

Dimethyltryptamine, ook bekend als DMT is een stof die in bepaalde planten zit, en die lijkt op de neurotransmitter serotonine.[1] DMT wordt wel het molecuul der sjamanen genoemd, of ook wel: The Spirit Molecule, door de beroemde DMT onderzoeker Dr Rick Strasmann [2], die zelfs een heel boek over deze stof schreef.

DMT: transpersoonlijke ervaringen en medische toepassingen

DMT staat weer volop in de belangsteeling, nadat bleek dat langdurig gebruik onze hersenen kan fine-tunen in de richting van transpersoonlijke ervaringen. [3] Preparaten die DMT bevatten worden dan ook tijdens meditatie en religieuze sessies ingezet om transpersoonlijke ervaringen verder te ondersteunen. [4]

DMT wordt in onze hersenen zelf aangemaakt, en valt onder de ethenogene groep der tryptamines.[5] De stof komt voor een vele, uiteenlopende planten. Een van die planten-extracten waarin DMT voorkomt is ayahuasca.[6] Daarvan zijn aanwijzingen dat het depressie tegen gaat, en dat gebruik veilig is. [7][8] Tevens lijkt het erop dat ayahuasca ingezet kan worden bij drugverslaafden tijdens afkick perioden. [9] Ook kan het molecuul mogelijk ontstekingen in de hersenen tegen gaan. [10]

DMT onderzoek al oud

Onderzoek naar de biologische en farmacologische alsmede etheogene eigenschappen van DMT is al vrij oud, meer dan een halve eeuw. [11] Al snel werd ontdekt dat monoamine oxidase DMT afbreekt. [12] In de jaren 60 werd DMT onderzoek vaak uitgevoerd hand in hand met andere entheogenen zoals mescaline en LSD. [13][14][15][16] Ook vond men het molecuul in verschillende planten, en merkte men de overeenkomst tussen DMT en in onze hersenen aanwezige tryptamines en de relatie met de pijnappel klier. [17][18][19] Het onderzoek breidde zich snel uit en inmiddels zijn er meer dan 1000 wetenschappelijke artikelen over DMT in pubmed, de medische databank.

Dr Srassmann, hoogleraar psychiatrie, openbaarde recent nieuwe gegevens over dit bijzondere molecuul, dat ook weer door onze noeste vaderen des vaderlands in de ban gedaan is als verboden molecuul. Boeiend dat we een stukje van onszelf en een molecuul uit de natuur op de verboden lijst kunnen zetten.

Hieronder de nieuwsflits over het werk van Dr Strassmann.

Dr Strassmann en DMT, de ontsluiter van de geest

Rick Strassman MD performed the first new human studies with psychedelic drugs in the US in over 20 years. His research involved the powerful naturally-occurring compound, DMT – N,N-dimethyltryptamine. Led to this substance through his earlier study of the pineal gland as a potential biological locus for spiritual experiences, he administered several hundred doses of DMT to approximately 60 volunteers between 1990 and 1995. He wrote about this research in the popular book, DMT: The Spirit Molecule, which has sold over 100,000 copies, has been translated into 12 languages, and is now available as an audio-book. It also inspired an independent documentary by the same name, picked up by Warner Bros distributing in Fall, 2011. With three distinguished collaborators, he co-authored Inner Paths to Outer Space, which looks more carefully at the common “other worlds” experience that volunteers frequently reported during his research.

Since 1996, Dr. Strassman has been exploring models for the DMT effect focusing primarily on the Old Testament concept of prophecy. Prophecy is a spiritual experience which takes into account the apparently external, free-standing nature of the DMT “worlds,” in which one’s sense of self is highly preserved and interactive. The Old Testament concept of prophecy provides an alternative to other models that borrow more heavily from Eastern religious systems, and those of Latin American shamanism. The notion of prophecy also deals directly with ethical and moral concerns, adding a crucial element to our ability to understand and integrate the content of the psychedelic experience. He is developing these ideas in his next book, The Soul of Prophecy, due to appear in 2013.

Dr. Strassman is currently Clinical Associate Professor of Psychiatry at the University of New Mexico School of Medicine. He is also President and co-founder of the Cottonwood Research Foundation, which is dedicated to consciousness research.

You may purchase DMT: The Spirit Molecule, and Inner Paths to Outer Space directly from the author on this site. Dr. Strassman does his best to answer every e-mail sent to him, so please feel free to make contact.


At long last, I’m delighted to announce the completion of my latest book: DMT and The Soul of Prophecy.Click here for the link to the book on my publisher’s (Inner Traditions) website. If editing goes according to plan, the book should appear in print late September this year.

In this book, I tackle the major unresolved issue with which I was left after finishing my DMT project nearly 20 years ago. This was to find a model that fit the data from our volunteers’ reports of the drug state. This ultimately led me to the Old Testament (Hebrew Bible) where the notion of a “prophetic state of consciousness” began taking shape. At the same time, in order to make sense of the Hebrew Bible, I turned to the classic medieval Jewish philosophers like Maimonides, who proposed rather sophisticated metaphysical/spiritual mechanisms for the prophetic experience. Thus, to the extent that the prophetic and DMT states resembled each other, I could propose metaphysical and spiritual mechanisms in common in addition to shared biological mechanisms.

DMT and The Soul of Prophecy is now on and the other major online retailers for pre-order. Or, you may preorder it from me below or from Inner Traditions to assure that you receive the first printing. If you order it from me, I will sign and inscribe the book.

Click here to read more.


I am pleased to announce that the DMT documentary, “DMT: The Spirit Molecule,” is now available onNetflixAmazon and iTunes. Nearly 5 years in the making, the film condenses over 80 hours of interview footage with cutting-edge computer-generated imagery to capture critical elements of the DMT experience. I am quite happy with the result, and encourage you to enjoy the film, spread the word.


[1] Alonso JF1, Romero S2, Maanas M1, Riba J3. | Serotonergic psychedelics temporarily modify information transfer in humans. | Int J Neuropsychopharmacol. | 2015 Mar 28. pii: pyv039. doi: 10.1093/ijnp/pyv039. [Epub ahead of print]

[2] Barker SA1, McIlhenny EH, Strassman R. | A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010. | Drug Test Anal. | 2012 Jul-Aug;4(7-8):617-35. doi: 10.1002/dta.422. Epub 2012 Feb 28.

[3] Bouso JC1, Palhano-Fontes F2, Rodrguez-Fornells A3, Ribeiro S2, Sanches R4, Crippa JA4, Hallak JE4, de Araujo DB2, Riba J5. | Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans. | Eur Neuropsychopharmacol. | 2015 Apr;25(4):483-92. doi: 10.1016/j.euroneuro.2015.01.008. Epub 2015 Jan 16.

[4] Gaujac A1, Dempster N, Navickiene S, Brandt SD, de Andrade JB. | Determination of N,N-dimethyltryptamine in beverages consumed in religious practices by headspace solid-phase microextraction followed by gas chromatography ion trap mass spectrometry. | Talanta. | 2013 Mar 15;106:394-8. doi: 10.1016/j.talanta.2013.01.017. Epub 2013 Feb 1.

[5] Arajo AM1, Carvalho F, Bastos ML, Guedes de Pinho P, Carvalho M. | The hallucinogenic world of tryptamines: an updated review. | Arch Toxicol. | 2015 Apr 16. [Epub ahead of print]

[6] Riba J1, McIlhenny EH, Valle M, Bouso JC, Barker SA. | Metabolism and disposition of N,N-dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca. | Drug Test Anal. | 2012 Jul-Aug;4(7-8):610-6. doi: 10.1002/dta.1344. Epub 2012 Apr 19.

[7] Osrio Fde L1, Sanches RF1, Macedo LR1, Dos Santos RG1, Maia-de-Oliveira JP2, Wichert-Ana L1, de Araujo DB3, Riba J4, Crippa JA1, Hallak JE1. | Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. | Rev Bras Psiquiatr. | 2015 Jan-Mar;37(1):13-20. doi: 10.1590/1516-4446-2014-1496.

[8] Barbosa PC1, Mizumoto S, Bogenschutz MP, Strassman RJ. | Health status of ayahuasca users. | Drug Test Anal. | 2012 Jul-Aug;4(7-8):601-9. doi: 10.1002/dta.1383. Epub 2012 Jul 4.

[9] Liester MB1, Prickett JI. | Hypotheses regarding the mechanisms of ayahuasca in the treatment of addictions. | J Psychoactive Drugs. | 2012 Jul-Aug;44(3):200-8.

[10] Szabo A1, Kovacs A2, Frecska E2, Rajnavolgyi E1. | Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. | PLoS One. | 2014 Aug 29;9(8):e106533. doi: 10.1371/journal.pone.0106533. eCollection 2014.

[11] KAJTOR F. | [Effect of dimethyltryptamine (DMT) on the electroencephalogram of normal individuals]. | Ideggyogy Sz. | 1958 Oct;11(4):122-6.

[12] SMITH TE, WEISSBACH H, UDENFRIEND S. | Studies on the mechanism of action of monoamine oxidase: metabolism of N,N-dimethyltryptamine and N,N-dimethyltryptamine-N-oxide. | Biochemistry. | 1962 Jan;1:137-43.


[14] Khazan N, McCash D. | Effects of LSD-25, n,n-dimethyltryptamine (DMT), and N,N-diethyltryptamine (DET) on the photic evoked responses in the unanesthetized rabbit. | Arch Int Pharmacodyn Ther. | 1965 Apr;154(2):474-83.

[15] Randi? M, Padjen A. | Effect of N,N-dimethyltryptamine and D-lysergic acid diethylamide on the release of 5-hydroxyindoles in rat forebrain. | Nature. | 1971 Apr 23;230(5295):532-3.

[16] Smythies JR, Bradley RJ, Johnston VS, Leonard F. | The behavioural effects of some derivatives of mescaline and N,N-dimethyltryptamine in the rat. | Life Sci. | 1967 Sep 1;6(17):1887-93.

[17] Lai A, Tin-Wa M, Mika ES, Persinos GJ, Farnsworth NR. | Phytochemical investigation of Virola peruviana, a new hallucinogenic plant. | J Pharm Sci. | 1973 Sep;62(9):1561-3.

[18] Heller B, Fischer E, Spats H. | N,N-dimethyltryptamine like substance in rat brain. | Life Sci. | 1973 Aug 16;13(4):313-6.

[19] Guchhait RB. | Biogenesis of 5-methoxy-N,N-dimethyltryptamine in human pineal gland. | J Neurochem. | 1976 Jan;26(1):187-90.

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