Palmitoylethanolamide (PEA) is an anti-inflammatory body own molecule and might be able to fight off part of the neuro-inflammation in ALS.
Simonetta Clemente (MD) from the Macomer Rehabilitation Center, Nuoro Health Care Center, Italy published an important mile stone paper in 2012, title: ‘Amyotrophic Lateral Sclerosis Treatment with Ultramicronized
Palmitoylethanolamide: A Case Report’.
In this paper she descibes the positive effect of the natural and body-own compound palmitoylethanolamide (PEA) in ALS, amyotrophic lateral sclerosis, a devasting neurological disorder also known as Lou Gehrig’s disease in the USA.
In her article she points out that PEA has potent anti-inflammatory activity in many acute and
inflammatory and chronic pain models, that PEA reduces spinal cord trauma
in mice, and has neuroprotective properties.
She refers to the recent findings from professor’s Cruccu’s group, that PEA has seen to
improve myelinated-fibre function in patients with
chemotherapy-induced painful neuropathy and to other recent publications were PEA was seen to reduce pain severity in patients with pain associated to
different pathological conditions who were undergoing
standard therapies with unsatisfactory results or in those
patients who discontinued standard therapy because of
important side effects.
Given the lack of an effective
therapy for ALS, as she correctly stated, she explored and reported the effects of PEA in a
case of ALS.
It happens often that what patients perceive as most effective treatments, usually doctors see as less important, and what doctors see as most important, based on our evidence based medicine, patients see as undesirable and less effective! Oeps! This is not just a blurp from a doctor of alternative medicine. These are data from a survey among hundreds of spinal cord injury patients, conducted by experts from a world famous institute, the Dutch Rudolf Magnus Institute of Neuroscience and Centre of Excellence for Rehabilitation Medicine, from the University Medical Centre in Utrecht.
Back pain is common in both dogs and humans, and a new treatment without side effects based on the all natural painkiller palmitoylethanolamide (PeaPure or Normast) is now available. PeaPure is available via a webshop in Europe and produced in the Netherlands according to GMP; Normast is available in Spain and Italy, and available in pharmacies. PeaPure is probably the best alternative for dogs, due to the absence of chemical fillers.
Back pain is often associated with intervertebral disc (IVD) degeneration.
Dr. Bergknut, N. wrote a PhD thesis on this topic, publihed in Acta Universitatis Agriculturae Sueciae, Volume: 2010, Issue: 91 (2011), from which we quote parts of the summary.
Horses often suffer from chronic pain states related to running, jumping or other movement- related disorders. Mostly either vetenarian analgesics or supplements are administered. The vetenarian analgesics have a clear drawback, namely various side effects, and most of the supplements are not scientifically well established as effective treatments.
Especially the use of corticosteroids and analgesics give rise to side effcts in horses wich can compromise their functions and quality of life.
The body own analgesic and anti inflammatory agent palmitoylethanolamide can be succesfully applied to horses and horses suffering chronic pain and/ or inflammation. Many studies in various animals have proven the efficacy and safety of palmitoylethanolamide. The compound also has relevant efficacy in horses, as we will demonstrate in the following cases.
In nature animals have always been threatened by inflammation and pain. Inflammation and pain often go hand in hand. Often pain and inflammation are natural strategies of animals to survive: pain indicates and acts as an emergency signal, and inflammation kills bacteria and viruses.
However, there are types of pain and inflammation who are no good for survival. In man we know these states as auto-immune disorders, diseases such as rheumatoid artritis, inflammatory bowel disorder and the like.
In these cases the body itself attacks the tissues of the body itself, for no obvious reason at all. Inflammation without infection, without bacteria or viruses attacking our body we call aseptical inflammation. Chronic inflammation and pain are the base for a variety of disorders leading to unhappy horses. Some of these are: synovitis (inflammation joint membranes), artritis, tendinitis, colitis, skin hypersensitivity and eczema and many non-bacterial inflammations more.
Inflammation is a natural defence mechanism against tissue injury and usually leads to successful tissue healing. Sometimes, the inflammatory process itself actually causes further injury. In such circumstances it is appropriate to intervene with analgesic (pain-killing) and anti-inflammatory drugs. We will demonstrate the usefulness of a natural painkiller and anti-inflammatory compound, which is regarded as a breakthrough in the treatment of pain and inflammation.
An interesting new therapeutic approach for the rehabilitation and Amyotrophic Lateral Sclerosis hasl been presented in Milan, during the second day of the XII National Congress of SIRN, the Italian Society of Neurological Rehabilitation.
The new hope in the treatment of ALS, neuro-degenerative disease that affects about one in every 100 (mostly men of middle or advanced age), and in 5% of cases are familial, comes from "palmitoylethanolamide" (PEA).
It is an endogenous compound with anti-inflammatory effect cannabinergico, discovered years ago by Italian scientists in the group that included, among others, the Nobel Prize Professor Rita Levi Montalcini.
PEA for ALS: further information
Palmitoylethanolamide is available in the Netherlands as a food supplement, up to November 2012 as Normast and from November 2012 onwards as a new supplement, under the brandname PeaPure.
There are some important differences between Normast and PeaPure , but both supplements contain the body own anti-inflammatory compound palmitoylethanolamide.
In PeaPure you find in one package 30 capsules of 400 mg pure palmitoylethanolamide, without any other pharmaceutical substance, nor sweeteners.
In Normast you find in one package either 20 sachets containing 600 mg palmitoylethanolamide with ca 300 mg sorbitol (a sweetener) or a package with 20 tablets containing palmitoylethanolamide and magnesium stearate and other farmaceutical fillers.
The capsules of PeaPure are specially designed to be used either for obtaining filely powdered palmitoylethanolamide, to administer under the tongue (the capsule has been developed so that opening is easy and one can sprinkel the powder or directly in the mouth, or on a spoon and then under the tongue). The company developed PeaPure without any sweetener, because patients gave the input that the sweetener induced sometimes diarree. Or the sweetener, most of the time, induced so much slime/saliva in the mouth, that it was difficult not to swallow.
Russell Science Ltd therefore developed this content of the capsule, the pure palmitoylethanolamide itself, with a neutral taste by not adding sorbitol, to not attrack saliva and avoid the side effect of diarree.
How to take PEA in the ALS?
The best is to start with either Normast in 2 times 600 mg sachets or with 3 capsules of PeaPure 400 mg and sprinkel the powder in the mouth. After the second day double the dose, and use 3 times 2 capsules. After 10 days, if it is convenient, one can swallow a capsule three times a day and use also the pwder from 3 capsules three times a day under the tongue.
If started with Normast powder, add Normast 600 mg tablets after a week, to increase the dose, or even double the dose.
Palmitoiletanolamida es un nuevo tratamiento natural de dolor crónico!
Rita Levi-Montalcini worked with Pure PEA
En 1993 descubrió y describió el premio Nobel de la Profesora Rita Levi-Montalcini funcionamiento del PEA. Ella también escribió que la PEA es una molécula natural muy importante.
Desde entonces, han pasado muchas cosas. Mientras tanto, miles de personas de todo el mundo utilizan a diario PEA. Para el dolor crónico y la inflamación crónica. El tejido es entonces docenas estudios investigaron un total de miles de pacientes. Está claramente demostrado ser eficaz y seguro.
La cystite est un mot difficile pour une infection de la vessie. La
cystite interstitielle est plus compliquée. Il s’agit d’une inflammation
chronique de la vessie, où les bactéries ne jouent aucun rôle. On estime que
plusieurs milliers de personnes dans notre pays souffrent de cette méchante maladie
de la vessie, et la plupart d’entre eux sont des femmes. Avant de parler de la
cystite interstitielle, le médecin traitant, un urologue ou un gynécologue doit
être consulté afin d’exclure l’existence d’une infection ou un cancer. Ce sont
les deux conditions qui causent le plus de problèmes et de douleurs en urinant.
Parce que «la cystite
interstitielle » est un terme difficile, nous utilisons plutôt le terme «syndrome
douloureux de la vessie ». Ce terme recouvre exactement la charge: c’est
douloureux, liés à la vessie et aucune maladie évidente mais un syndrome!
Treatment of neuropathic pain, an overview presented at the 3rd European Congress for Integrative Medicine, in Berlin, December 3rd, 2010. The founding fathers of the Institute of Neuropathic pain in Soest (NL) attended the above mentioned congress to present the integrated treatment concept for neuropathic pain to an audience of physicians interested in pain treatment. The director of research and development from the institute, professor Jan M. Keppel Hesselink, presented the multimodal therapy as it has been developed within the institute over the past years.
There is a new painkiller available in Germany and other European countries, based on a body own and all
natural compound which proved to be effective and without any troublesome
side effects, professor Jan M. Keppel Hesselink, pointed out at an
important medical congres in Italy on November 24-26, 2011. Leading international pain experts, such as the German professor Ralph Baron also spoke at that congres.
Keppel hesselink, holding a chair in molecular pharmacologist at the
University of Witten/Herdecke in Germany, presented a major breakthrough in chronic
pain treatment during the anual neurological congress for Italian
anesthesiologists and painspecialists (SAARTI). While nearly all painkillers available
inhibit pain via the nerve cells, Keppel Hesselink pointed out that a
totally different and natural approach via the modulation of the so called glia cells
has been overseen. The compound is available as the foodsupplement PeaPure and as Normast .